Comparable antigen-specific T cell responses in vaccinees with diverse humoral immune responses after the primary and booster BBIBP-CorV vaccinationArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료제, [키워드] Anti-spike Antibody Response B cell B cell responses BBIBP-CorV booster booster vaccination CD4 CD8 comparable COVID-19 COVID-19 vaccines de novo demonstrated detectable dramatic increase Epidemic exhibited Features humoral immune response Humoral immunity humoral responses interferon-γ Neutralizing antibodies omicron remained S protein SARS-CoV-2 SARS-COV-2 infection serotype Severe case Shanghai significantly T cell T cell response T cell responses T cell responses. Th1 cytokine vaccination vaccinee vaccinees wild type [DOI] 10.1080/22221751.2022.2130101 PMC 바로가기
IgA nephropathy with glomerular capillary IgA deposition following SARS-CoV-2 mRNA vaccination: a report of three casesArticle Published on 2022-11-012022-11-15 Journal: CEN case reports [Category] COVID19(2023년), SARS, 진단, [키워드] acute deterioration acute exacerbation acute respiratory syndrome addition coronavirus COVID-19 de novo diagnosed glomerular Hematuria histological IgA IgA nephropathy kidney lesions mRNA mRNA vaccine mRNA vaccine. nephropathy Patient proliferation relapsing SARS-CoV-2 SARS-CoV-2 vaccination Therapies Urinalysis Vaccinations [DOI] 10.1007/s13730-022-00707-0 PMC 바로가기
Association between SARS-CoV-2 infection and de novo HLA donor specific antibody production in lung transplant recipients: Single-center studyArticle Published on 2022-11-012022-11-15 Journal: Human immunology [Category] SARS, 진단, 치료기술, [키워드] antibody antibody production association COVID-19 COVID-19 pandemic de novo diagnosed with COVID-19 Diagnosis Donor donor specific antibodies HLA HLA antibodies HLA class I incidence include Infection LTR lung transplant lung transplant. MFI morbidity and mortality no significant difference outcome performed raised recipient recipients respiratory retrospective SARS-COV-2 infection the median viral infection [DOI] 10.1016/j.humimm.2022.07.007 PMC 바로가기
De novo selected hACE2 mimics that integrate hotspot peptides with aptameric scaffolds for binding tolerance of SARS-CoV-2 variantsArticle Published on 2022-10-282022-11-15 Journal: Science Advances [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acute respiratory syndrome Antiviral binding coronavirus Critical de novo evade exhibited hACE2 host cell hotspot human Angiotensin-converting enzyme immune in vitro Interaction Ligand Neutralizing nucleic acids Occurrence omicron peptide Prophylaxis random reagents Receptor binding receptors recruit SARS-CoV-2 SARS-CoV-2 variant selected Tolerance Vaccine variant variants viral variant virus [DOI] 10.1126/sciadv.abq6207 PMC 바로가기
CD169-mediated restrictive SARS-CoV-2 infection of macrophages induces pro-inflammatory responsesArticle Published on 2022-10-242022-11-15 Journal: PLoS Pathogens [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] ACE2 activated Activation alleviate Antigen CD169 CD169+ macrophage contribute COVID-19 pathology COVID-19 patients de novo elicited exogenous ACE2 expression expression of SARS-CoV-2 facilitated genomic humans Hyperinflammatory IL-1β IL-6 independent induce Infection innate immune response Macrophage macrophages MDA-5 monocyte myeloid cell Post-mortem primary target cell pro-inflammatory cytokine pro-inflammatory response Remdesivir Replication Restricted RIG-I RNA SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection subgenomic RNA subsequent suppressed the SARS-CoV-2 thought TNFα Treatment viral particle Viral protein Viral RNA [DOI] 10.1371/journal.ppat.1010479 PMC 바로가기
New-onset dermatomyositis following COVID-19: A case reportArticle Published on 2022-10-242022-11-16 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome addition anti-aminoacyl tRNA synthetase (ARS) antibodies anti-synthetase antibodies antibodies antibody association autoantibody Autoimmune Autoimmune disease Autoimmune diseases biochemical analysis Biological Case report caused Chest clinical feature Clinical features complications Computed tomography contributed coronavirus Coronavirus disease 2019 Corticosteroids cough COVID-19 de novo dermatomyositis dermatomyositis. develop diagnosed diagnostic Dyspnea edema elevations enzyme-linked immunosorbent exacerbate Fever highlight Hospitalization IgG ILD immunoblot infected individual Infectious disease Inflammatory interstitial Interstitial lung disease Japan Japanese lower lobe Lungs male manifestation MOST myalgia myopathies myositis Occurrence organ pathological findings Patient polymerase chain positive Prednisolone presenting profile respiratory symptom SARS-CoV-2 skin rash sore throat Swab syndrome tested transaminases treated tRNA weakness [DOI] 10.3389/fimmu.2022.1002329 PMC 바로가기
Live and let die: signaling AKTivation and UPRegulation dynamics in SARS-CoVs infection and cancerArticle Published on 2022-10-032022-11-16 Journal: Cell Death & Disease [Category] COVID19(2023년), SARS, 신약개발, 유전자 메커니즘, [키워드] acute respiratory syndrome AKT Cancer Cell Comorbidity coronavirus coronavirus disease COVID-19 de novo death deregulated drug Drug discovery Evidence feedback homeostasis homeostatic Infection Interaction maintain mechanism opposite pandemic pathogen pathway Pathways progression recent reduce regulate Regulation response responsible SARS-CoV SARS-CoV-2 SARS-COV-2 infection shown Signaling signaling cascade significantly survival therapeutic purposes Topic Treatment UPR viral infection viral infections [DOI] 10.1038/s41419-022-05250-5 PMC 바로가기
Screening for antibodies to HLA class I in apheresis donors following Covid-19 or SARS-CoV-2 vaccinationArticle Published on 2022-10-012022-11-15 Journal: Transfusion and apheresis science : official journ [Category] COVID19(2023년), SARS, 진단, [키워드] addition analyzed antibody Blood blood components blood donor blood sample boost conducted de novo deaths Donor donors expression groups healthy blood donors HLA HLA class I Hypothesis immune response immunization Implications Infection mRNA pandemic patients plasma responsible SARS-CoV-2 vaccination SARS-CoV-2 virus screened Screening Support the vaccine transfusion vaccination Vaccines virus [DOI] 10.1016/j.transci.2022.103567 PMC 바로가기
Native, engineered and de novo designed ligands targeting the SARS-CoV-2 spike proteinSARS-CoV-2 스파이크 단백질을 표적으로 하는 네이티브, 엔지니어링 및 드노보 디자인 리간드Review Published on 2022-10-012022-09-12 Journal: Biotechnology advances [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE2 acute respiratory syndrome affinity Affinity ligands antibody binding Cell concerning Contact coronavirus coronavirus disease de novo de novo design. develop diagnostic diagnostics hACE2 Host human Angiotensin-converting enzyme in vivo infect Interaction lesson Ligand ligands molecular Native natural pandemic Pandemics Patient Prophylactic Protein public health receptor reported responsible S-protein SARS-CoV-2 SARS-CoV-2 proteins Scientific community spike Spike protein the SARS-CoV-2 therapeutic therapy Vaccine virus yielding [DOI] 10.1016/j.biotechadv.2022.107986 PMC 바로가기 [Article Type] Review
Brequinar and dipyridamole in combination exhibits synergistic antiviral activity against SARS-CoV-2 in vitro: Rationale for a host-acting antiviral treatment strategy for COVID-19Research article Published on 2022-10-012022-10-05 Journal: Antiviral Research [Category] COVID19(2023년), SARS, 변종, 치료법, 치료제, [키워드] acute respiratory syndrome Antiviral antiviral activity Antiviral treatment B.1.351 B.1.617.2 Beta Brequinar cellular Combination coronavirus coronavirus disease COVID-19 de novo deaths Delta DHODH Dihydroorotate dehydrogenase (DHODH) Dipyridamole drug treatments effective enzyme evade Evolution of SARS-CoV-2 exhibit global pandemic Host host cell in vitro Infection infections inhibitor maintain medical need monoclonal antibody nucleotide pathway rationale Replication required resulting RNA virus SARS-CoV-2 SARS-COV-2 infection selective shown Support synergistic therapy treat Treatment Vaccine variants viral replication [DOI] 10.1016/j.antiviral.2022.105403 [Article Type] Research article